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Jasbg, thanks. Love Santana. Abraxas was the first 8-Track tape I purchased around 1970. Carlos has a unique and soulful gift with the guitar.
Everyone left him alone where we ate . Lot of music people in my town so no big thing .
Actually wandered into Sammy Haggers backyard once ...got off trail , hiking .
Helped a friend do some repair work on a house ...went into the basement and found Jerry Garcia's gold records lying around. Apparently was his girlfriends house at the time
Kiwi
Still playing in Vegas Jas
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Come on Denner ...do your thing
Nissen
Santana goes to out frequently in Summerlin Las Vegas. And he always dressed like Santana. Kind of weird. I would want to eat in peace
Livin in Las Vegas Meet up with me and Jas ...if he's still performing ...and if AMRN gets sold over $5
Santana is great live
Nissen ( can't type Dr Nissen in case I get a cease and desist order ...:--)
Santana came to Montreal in 1982 but alas, I had moved away in 1978, and never got a chance. Would have to say that the most memorable performance I went to was Led Zeppelin in 1970. A couple of years later went to a Sly and The Family Stone concert and it was a disaster. Sly Stone had laryngitis and instead of cancelling the show and refunding us, they went on with it.
Apparently Santana had heart surgery in Dec. 2021. Still alive though.
Jas. actually see if you can find a clip on Santana and Mana ...probably the best live concert I've ever been to
I've posted that I've been buying AMRN under $1
Why buy AMRN ?
Co has EU patent protection out to 2039 . At some pt , one would hope , Denner et al can find a way to meaningfully crack the remaining big 3 EU markets .
That may take ... close your eyes and cover your ears ...some Real World Evidence or small follow up trials because I doubt they will make much headway with their current approach
ANYWAY .....should they finally get it together and get AMRN sold for over $5 ...I'll pay for your flight to Las Vegas to see Santana play if he's still performing .
You'll have to pay for your own Motel 6 room
Your pal. Nissen ...I'm serious about paying for your ( regular economy class ) flight .
Jas. probably the best live show I've ever been to .
Santana used to occasionally hang out at a local restaurant we went to
Your friend ..Dr Nissen ....:--)
Weekend ! We need some 'real' music in our ears to handle the current AMRN value:
DYK 141,700 ischemic stroke deaths occurred in the USA alone (2021)?
@Amarincorp @DLBHATTMD @SABOURETCardio @mmillermd1 @gabrielsteg @VietHeartPA #IPE #EPA #VAZKEPA #VASCEPA DYK there were 141,714 Ischemic Stroke Deaths (2021) in the USA alone? pic.twitter.com/g9uzTBg4z2
— Mike Everts (@GeoWizz_) May 17, 2024
Its difficult for Amarin to sue individual Docs for patent infringement...but pharmacy chains and pharmacy benefit managers(PBM's) and insurance companies are not immune from infringement suits.
Nuke...Docs hate wasting time, writing Rx's...Perhaps it would be a worthwhile trial for Amarin to distribute free Rx pads to Docs...inscribed, among the writings..."Vasepa 1 gram Q.I.D. P.O....along with the letters DAW".
Pharmacies would still ignore the Rx pads' DAW in some cases, but not in all.
At the very least, it would provide Docs with some inexpensive exposure to Vascepa, even if many Docs eventually throw the Rx pads away, as many of them would.
Lem from your lips! Congrats on the new one and similarly with a three and five year old, is exactly why I’m on V and why we should be part of the marketing story to all middle aged men, dads or otherwise. What really chaps my ass about all of this is how safe and effective V is, and how disruptive it will be once in the hands of a capable pharma team to help promote not just CV risk reductions, but for other indications as well. I’ve previously mentioned my skin improvements, too, in having eczema issues my entire life. They’re all but gone now. On the safety note, our we got the beat commercial was just the tip of the marketing iceberg and I recall folks FUD’ing all over the side effects listed during the commercial. Not one of our side effects are as severe as the ones I heard just now on a Jardiance commercial, where for about 20 seconds they rattled off a host of potential side effects that “could result in death” and this one - possible loss of your lower limbs. Absolutely insane.
Or, some insurers have removed V from their formulary and no longer cover brand
You’re spot on. Doctors are prescribing generic because 1) either they’re stupid or 2) insurance companies are pushing back on DAW which is infringing.
We all know the gory details.
Congratulations on your baby girl. My youngest daughter just turned 24. I was 48 when my wife delivered our daughter.
Vascepa works!!!
OK, then it takes more than 18 months.
He will need more than 18 months as slow as this is going. The Germany approval is a year away very best case scenario.
An amended discovery confidentiality order, agreed to by both parties and signed by the magistrate judge in the Trenton antitrust case, should pose no problems. Details not necessary to us, and not available anyway.
Yes, see my previous post about an EPA threshold.
I recall seeing some Dose Response curves for EPA in control arm of REDUCE-IT vs. Placebo (I can't put my finger on it at the moment, but it showed a hazard ratio inflection point at about 100 mg/dl EPA suggesting a threshold near this value in order to show benefit. This may explain why STRENGTH may have missed that threshold. I'll see if I can find that reference.
Capt. Thx. I remember there being a lot of discussion around the optimal serum EPA levels as levels over the 4 gms daily used in R-IT may increase risk .
Theres this concept of therapeutic window .....high enough dose to confer benefit but not high enough to significantly increase risk / ae's
May confer higher risk of bleeding and Afib .
Kiwi
O. Thx Yes Japanese high fish diet with 1.8 gms of Epadel is roughly equal ( serum EPA ) to an American red meat diet plus 4 gms of Vascepa .
Kiwi
Japanese population if you recall.
Capt - Do you know what plasma EPA level would be considered as ideal? The more the plasma EPA level one wants would cost more but does that provide additional benefits to the patents
Capt. your chart is showing R-T 4 gms a day as less serum / plasma EPA then JELIS at 1.8 gms a day ?
Is that correct ?
Kiwi
Capt....Nice U.K. growth in Vascepa usage....What stood out for me in your charts is that there were 185 MILLION Lipitor doses and only 189 THOUSAND doses of Vaskepa
Since most of the patients presently on Lipitor would be able to benefit by being on Vascepa, in addition to a statin...these figures point out the potential for outstanding growth in future Vaskepa sales volumes in the U.K.!
Sleven, what’s that mean? Please share in more details
Thanks for posting. Good stuff.
May be one of Nissen’s surrogates.
RMB, In China it's not about infringement. It's about reimbursement. If they don't have the indication they will not get reimbursement
Sleven,
CBB, I don’t disagree that Vascepa is best-suited in the hands of BP. However, Denner still wants to get top dollar for the company, and not just give it away. And that will require more progress towards approvals and reimbursement in EU.
Denner wants to remove as much risk and uncertainty from Amarin before putting it up for sale. I think we need 18 months.
As if that matters ( illegal infringement ) , in China
Congrats on having a daughter Lem ...fun times ( mostly ) ahead
Kiwi
Like what is happening here in the U.S.
“Every man needs a daughter”
No truer words my friend. I fear I can never goto a strip club again…..
I am now and for ever her vassal.
Lem
Poignant post
Congratulations on the birth of your daughter
I have one and 4 granddaughters
Every man needs a daughter
Onward and upward!
It matters, selling without CV indication is illegal infringement.
EPA is pluripotent and effective. The drug or molecule “works”. Its unfortunate that JT used just that phrase way back when…I remember physically and intellectually cringing as I saw it live…..but he was not wrong…just the wrong man at the perfectly best and worst time…
I feel the winds changing. Vascepa’s day is coming albeit under a different master. AMRN’s days are numbered…but that’s a good thing….for longs.
I’ve brought a little girl into the world just recently and I’m taking V again to be sure I’m around for her. That’s the hokey commercial we need. A middle aged man taking his two Vascepa right before he gives the 3 am bottle to his little miracle….while the momma bear steals some sleep. He takes it today so he can be there tomorrow.
I’m not sure if it’s the little one’s hormones or my brain waking up and doing crazy hormonal things, but I got some acne the other day and my skin has become 10 years younger. It’s the three weeks of V after a long hiatus or the babe or both. Either way…we gonna be ok. We just not gonna be AMRN for much longer.
JRoon71, One problem I always had with Amarin is that it was and still is unknown to the world.
For a BP to give its weight to any drug could make difference as to the success or failure of that
drug. That is why I so convinced that only a Eurocentric BP is capable of turning Vazkepa into
a success. Europe is the only place where Vazkepa has a long-term exclusivity arrangement
without a competing drug. I understand the rationale for Denner to wait at least for Germany
to reimburse. However, Denner needs this to be in the hands of a Eurocentric BP. GIA is suicide.
With or without Germany, France, & Italy; a Eurocentric BP will be needed. Too bad Astra-Zenica
did not acquire AMRN but went with an EPA/DHA mix. I would imagine AZN had some big plans
if their drug had been a success. Today, on another message board I came across a poster who
was just diagnosed with ALS. My grandfather died of ALS in the early 1960s and I had a High School
friend who died of ALS at a young age. Amarin tested Vascepa on ALS at a dose of 1 gram a day
and the study failed with a trend towards efficacy. So much wasted potential with this drug!
Nice growth this month. Thanks Capt!
Thanks for posting Capt. Still such a slow increase. If we had a 15% increase each month we would have something to look forward to, but it seems when we have a good month then the next one is crappy.
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